ETH researchers from the Functional Materials Laboratory have developed a silicone heart that beats almost like a human heart. In collaboration with colleagues from the Product Development Group Zurich, they have tested how well it works.
It looks like a real heart. And this is the goal of the first entirely soft artificial heart: to mimic its natural model as closely as possible. The silicone heart has been developed by Nicholas Cohrs, a doctoral student in the group led by Wendelin Stark, Professor of Functional Materials Engineering at ETH Zurich. The reasoning why nature should be used as a model is clear. Currently used blood pumps have many disadvantages: their mechanical parts are susceptible to complications while the patient lacks a physiological pulse, which is assumed to have some consequences for the patient.
The goal was to develop an artificial heart that is roughly the same size as real one and which imitates the human heart as closely as possible in form and function. A well-functioning artificial heart is a real necessity: about 26 million people worldwide suffer from heart failure while there is a shortage of donor hearts. Artificial blood pumps help to bridge the waiting time until a patient receives a donor heart or their own heart recovers.
The soft artificial heart was created from silicone using a 3D printing, lost-wax casting technique; it weighs 390 grams and has a volume of 679 cm3. It is a silicone monoblock with complex inner structure. This artificial heart has a right and a left ventricle, just like a real human heart, though they are not separated by a septum but by an additional chamber. This chamber is in- and deflated by pressurized air and is required to pump fluid from the blood chambers, thus replacing the muscle contraction of the human heart.
Thinking in a new direction
Anastasios Petrou, a doctoral student of the Product Development Group Zurich, led by Professor Mirko Meboldt evaluated the performance of this soft artificial heart. The young researchers have just published the results of the experiments in the scientific journal Artificial Organs.
They proved that the soft artificial heart fundamentally works and moves in a similar way to a human heart. However, it still has one problem: it currently lasts for about only 3,000 beats, which corresponds to a lifetime of half to three quarters of an hour. After that, the material can no longer withstand the strain.
Still, this was simply a feasibility test. The researcher’s’ goal was not to present a heart ready for implantation, but to think about a new direction for the development of artificial hearts. Of course, the tensile strength of the material and the performance would have to be enhanced significantly.
Doctoral students of Product Development Group Zurich, who are working on new technologies for blood pumps, have developed a testing environment with which they can simulate the human cardiovascular system. The researchers of the silicone heart made use of this testing environment for their development process which also included the use of a fluid with comparable viscosity as human blood.